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The Mecsas lab works on two major topics in infectious diseases. The first project involves understanding how the bacterial pathogen, Yersinia, causes disease in mammals. Using a mouse model system of infection, we are investigating how the Yersinia Yops, which are injected into mammalian cells by a type III secretion system, inactive immune cells. In addition, we are investigating how Yersinia specifically targets host immune cells for Yop delivery.
The second project involves understanding how the type III secretion system works and how small molecules, which we have previously identified, inhibit type III secretion and Yop delivery into mammalian cells. In addition, we are exploring whether these small molecules are useful anti-infectives and whether they halt infection by Yersinia and other bacteria carrying type III secretion systems in mice.
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Some Biological and/or chemistry labs and course work |
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Carrying out experiments under the direction of the PI and a graduate student or post-doc |
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| Microbiology |
| Bacterial Genetics |
| Infectious Diseases |
| Immunology |
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